Suppression of viral release by host

Across TCGA patient cohorts, RNA activity of the Suppression of viral release by host pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAT2, PML, and XAF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Suppression of viral release by host activity versus STAT2 in LSCC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STAT2 →	+0.307	+0.097	<.001	.004	3	5
LUAD	PML →	+0.547	+0.172	<.001	.001	3	5
BRCA	XAF1 →	+0.578	+0.117	.001	.004	3	4
BRCA	RTP4 →	+0.915	+0.128	.001	.006	3	4
HNSC	OASL →	+1.042	+0.134	.005	.007	3	4
UCEC	NMI →	+0.438	+0.159	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044790 vs STAT2 — LSCC

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