Suppression of viral release by host

Across TCGA cell cohorts, RNA activity of the Suppression of viral release by host pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOOK1, HS6ST1, and GRB7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HOOK1 grouped by Suppression of viral release by host-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HOOK1 →	+1.821	+1.178	.008	.002	3	4
LIVER	HS6ST1 →	+1.817	+1.490	<.001	.006	3	4
LIVER	GRB7 →	+2.391	+1.724	.009	<.001	3	4
BLOOD_Myeloma	PCGF3 →	+1.132	+1.395	<.001	.001	3	4
BONE	POP4 →	-1.028	-1.831	.007	.002	3	4
LARGE_INTESTINE	OXSM →	-0.604	-1.033	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HOOK1 by Suppression of viral release by host activity — OVARY

Explore this box plot interactively →