Modulation by host of viral process

Across TCGA patient cohorts, RNA activity of the Modulation by host of viral process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN1, DAPK3, and FER, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by host of viral process activity versus TLN1 in LSCC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TLN1 →	+0.277	+0.036	<.001	.006	3	6
BRCA	DAPK3 →	+0.327	+0.035	.002	<.001	3	6
BRCA	FER →	+0.355	+0.043	<.001	<.001	3	6
UCEC	PPM1F →	+0.290	+0.064	.004	.008	3	6
UCEC	PPP1R18 →	+0.416	+0.094	.002	.001	3	6
UCEC	DPYD →	+0.493	+0.081	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044788 vs TLN1 — LSCC

Explore this scatter interactively →