Modulation by host of viral process

Across TCGA patient cohorts, RNA activity of the Modulation by host of viral process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFC5, NUCKS1, and MIR3135A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by host of viral process activity versus RFC5 in HNSC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RFC5 →	+0.398	+0.115	.005	.007	3	5
LSCC	NUCKS1 →	+0.488	+0.142	.005	.007	3	4
GBM	MIR3135A →	-0.742	-0.102	.002	.001	2	5
PDAC	PTGDS →	-0.819	-0.142	.001	<.001	3	4
PDAC	ABAT →	-0.561	-0.153	.001	<.001	3	4
LUAD	CD1E →	-0.853	-0.134	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044788 vs RFC5 — HNSC

Explore this scatter interactively →