Modulation by host of viral process

Across TCGA patient cohorts, RNA activity of the Modulation by host of viral process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRRM2_T2034, SRSF6_S316, and NUCKS1_S75, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by host of viral process activity versus SRRM2_T2034 in LUAD (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SRRM2_T2034 →	+1.065	+0.238	<.001	<.001	3	7
LUAD	SRSF6_S316 →	+0.952	+0.194	<.001	<.001	3	7
BRCA	NUCKS1_S75 →	+1.161	+0.237	<.001	<.001	3	7
GBM	SRSF7_S233 →	+0.930	+0.163	<.001	<.001	3	7
LUAD	SRRM2_S1112 →	+0.774	+0.222	<.001	<.001	3	6
LUAD	SRRM2_S2046 →	+1.249	+0.196	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044788 vs SRRM2_T2034 — LUAD

Explore this scatter interactively →