Cell cycle DNA replication

Across TCGA patient cohorts, RNA activity of the Cell cycle DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TROAP, XRCC2, and RAD54L, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell cycle DNA replication activity versus TROAP in GBM (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TROAP →	+1.041	+1.341	<.001	<.001	3	9
BRCA	XRCC2 →	+0.906	+0.757	<.001	.001	3	9
BRCA	RAD54L →	+0.817	+0.759	<.001	<.001	3	9
LUAD	CDCA8 →	+1.136	+1.153	<.001	<.001	3	8
GBM	ESPL1 →	+1.025	+1.438	<.001	<.001	3	8
LUAD	KIF11 →	+1.037	+0.889	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044786 vs TROAP — GBM

Explore this scatter interactively →