Cell cycle DNA replication

Across TCGA cell cohorts, RNA activity of the Cell cycle DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLPP, FARSB, and SZRD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell cycle DNA replication activity versus CLPP in STOMACH (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CLPP →	+0.784	+0.343	.001	.001	3	8
OVARY	FARSB →	+0.869	+0.532	<.001	.002	3	7
BREAST	SZRD1 →	+0.521	+0.213	.008	.004	3	6
OESOPHAGUS	PRMT3 →	+1.058	+0.234	.001	.002	3	6
BREAST	NASP →	+1.047	+0.282	<.001	<.001	3	6
BREAST	HNRNPA1 →	+0.686	+0.213	<.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044786 vs CLPP — STOMACH

Explore this scatter interactively →