Meiotic cell cycle phase transition

pathway activity — cross-omics
GO:0044771Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Meiotic cell cycle phase transition pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM4, TTK, and HJURP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADMCM4 →+0.963+0.453<.001<.00139
BRCATTK →+1.176+0.568<.001<.00139
BRCAHJURP →+1.157+0.576<.001<.00139
OVSGO1 →+1.063+0.671<.001<.00139
BRCAKIF2C →+1.481+0.646<.001<.00139
UCECCDC25C →+0.957+0.495<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration