Protein transmembrane import into intracellular organelle

Across TCGA patient cohorts, RNA activity of the Protein transmembrane import into intracellular organelle pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNJ1_S1565, PEX1, and MAP1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein transmembrane import into intracellular organelle activity versus SYNJ1_S1565 in OV (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SYNJ1_S1565 →	-0.410	-0.033	.002	<.001	3	5
BRCA	PEX1 →	+0.230	+0.022	.001	.002	3	5
LSCC	MAP1A →	+0.382	+0.028	.002	.004	3	5
LUAD	SON_S2238 →	-0.464	-0.023	<.001	.003	3	4
PDAC	SRRM1_S402 →	-0.449	-0.024	.005	.005	3	4
LUAD	FRY_S1940 →	+0.409	+0.021	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044743 vs SYNJ1_S1565 — OV

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