Protein transmembrane import into intracellular organelle

Across TCGA patient cohorts, RNA activity of the Protein transmembrane import into intracellular organelle pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPARCL1, SNED1, and CLEC14A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein transmembrane import into intracellular organelle activity versus SPARCL1 in UCEC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPARCL1 →	-1.386	-0.225	.003	.003	3	7
PDAC	SNED1 →	-0.528	-0.232	<.001	.001	3	7
LSCC	CLEC14A →	-0.594	-0.263	<.001	<.001	3	7
OV	SRPX →	-1.206	-0.143	.001	.003	3	6
OV	PDGFRB →	-1.809	-0.197	<.001	<.001	3	6
OV	ZEB1 →	-1.199	-0.146	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044743 vs SPARCL1 — UCEC

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