Protein transmembrane import into intracellular organelle

Across TCGA cell cohorts, RNA activity of the Protein transmembrane import into intracellular organelle pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNPY3, PLEKHG1, and GNE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNPY3 grouped by Protein transmembrane import into intracellular organelle-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CNPY3 →	-0.818	-1.007	.007	.007	3	4
BLOOD_Leukemia	PLEKHG1 →	+1.111	+0.977	.006	.002	3	4
LARGE_INTESTINE	GNE →	-1.134	-0.655	.007	.004	3	4
LUNG_NSCLC_LUSC	C6orf89 →	-1.016	-1.546	<.001	.005	3	4
LUNG_NSCLC_LUAD	C2CD2 →	-0.941	-0.649	.002	.002	3	4
LUNG_NSCLC_LUAD	FAM20C →	-1.991	-0.675	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNPY3 by Protein transmembrane import into intracellular organelle activity — KIDNEY

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