Protein transmembrane import into intracellular organelle

Across TCGA cell cohorts, RNA activity of the Protein transmembrane import into intracellular organelle pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf174, ZNF492, and CPTP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein transmembrane import into intracellular organelle activity versus C1orf174 in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C1orf174 →	+0.380	+0.273	<.001	.001	3	4
BLOOD_Leukemia	ZNF492 →	+0.822	+0.345	.001	.001	3	4
SOFT_TISSUE	CPTP →	+1.189	+0.520	<.001	.002	2	5
SOFT_TISSUE	CAB39L →	-1.373	-0.610	.009	.004	3	4
CNS	SP4 →	+0.564	+0.262	.002	.005	3	4
LUNG_SCLC	NUP42 →	-0.411	-0.271	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044743 vs C1orf174 — LUNG_NSCLC_LUAD

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