Epigenetic programming in the zygotic pronuclei

Across TCGA patient cohorts, RNA activity of the Epigenetic programming in the zygotic pronuclei pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3B3, ADNP, and PRPF19, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epigenetic programming in the zygotic pronuclei activity versus SF3B3 in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SF3B3 →	+0.281	+0.075	<.001	<.001	3	9
GBM	ADNP →	+0.333	+0.084	.001	<.001	3	9
LSCC	PRPF19 →	+0.272	+0.068	<.001	<.001	3	9
LSCC	WDR5 →	+0.327	+0.070	<.001	<.001	3	8
LSCC	CSTF1 →	+0.278	+0.079	<.001	<.001	3	8
LSCC	DHX9 →	+0.368	+0.090	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044725 vs SF3B3 — LSCC

Explore this scatter interactively →