"Protein import into peroxisome matrix, substrate release"

Across TCGA cell cohorts, RNA activity of the "Protein import into peroxisome matrix, substrate release" pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RECQL4, MACF1, and ZNF169, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RECQL4 grouped by "Protein import into peroxisome matrix, substrate release"-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RECQL4 →	+1.123	+2.052	.006	<.001	1	6
BLOOD_Myeloma	MACF1 →	-0.997	-1.831	.001	<.001	3	4
OVARY	ZNF169 →	-0.590	-1.142	.002	<.001	3	4
OVARY	MFSD14C →	-0.809	-1.406	<.001	<.001	3	4
LUNG_SCLC	ZNF451 →	+0.980	+1.635	.002	<.001	3	3
LUNG_SCLC	RAD54B →	+0.655	+1.218	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RECQL4 by "Protein import into peroxisome matrix, substrate release" activity — URINARY_TRACT

Explore this box plot interactively →