Multi-multicellular organism process

Across TCGA patient cohorts, RNA activity of the Multi-multicellular organism process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL3A1, FILIP1L, and COL6A3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multi-multicellular organism process activity versus COL3A1 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL3A1 →	+0.956	+0.058	<.001	<.001	3	9
UCEC	FILIP1L →	+0.687	+0.041	.001	<.001	3	9
GBM	COL6A3 →	+1.173	+0.055	<.001	<.001	3	9
OV	PALLD →	+0.743	+0.030	<.001	.006	3	9
OV	SULF1 →	+0.994	+0.037	<.001	<.001	3	8
UCEC	THBS3 →	+0.676	+0.050	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044706 vs COL3A1 — GBM

Explore this scatter interactively →