Multi-multicellular organism process

Across TCGA patient cohorts, RNA activity of the Multi-multicellular organism process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINE1, GIMAP7, and NRIP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multi-multicellular organism process activity versus SERPINE1 in CCRCC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SERPINE1 →	+1.045	+0.164	.006	.005	3	5
HNSC	GIMAP7 →	-1.037	-0.137	.005	.003	3	5
PDAC	NRIP3 →	+0.497	+0.160	.002	.003	3	5
HNSC	TMEM45A →	+1.352	+0.179	.009	.001	3	5
LSCC	TRAV9-2 →	-1.213	-0.291	.003	.001	3	5
HNSC	PPP1R16B →	-0.788	-0.131	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044706 vs SERPINE1 — CCRCC

Explore this scatter interactively →