Multi-multicellular organism process

Across TCGA cell cohorts, RNA activity of the Multi-multicellular organism process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGN4, PGAM1, and PPP3CC, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HMGN4 grouped by Multi-multicellular organism process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HMGN4 →	-0.423	-0.600	.004	<.001	3	3
BONE	PGAM1 →	-0.675	-1.021	.008	.005	3	3
LARGE_INTESTINE	PPP3CC →	-0.733	-0.145	.003	<.001	3	3
LARGE_INTESTINE	TBC1D20 →	-0.574	-0.157	.003	.001	3	3
LARGE_INTESTINE	ARHGAP22 →	-1.304	-0.117	.005	.005	3	3
LARGE_INTESTINE	NTMT1 →	-0.421	-0.131	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HMGN4 by Multi-multicellular organism process activity — SKIN

Explore this box plot interactively →