Adhesion of symbiont to host cell

Across TCGA patient cohorts, RNA activity of the Adhesion of symbiont to host cell pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZDHHC13, RASSF4, and IFFO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adhesion of symbiont to host cell activity versus ZDHHC13 in HNSC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZDHHC13 →	-0.355	-0.116	<.001	<.001	3	4
LUAD	RASSF4 →	+0.422	+0.117	<.001	<.001	3	4
LUAD	IFFO1 →	+0.413	+0.106	<.001	<.001	3	4
BRCA	MIR4435-2HG →	+0.289	+0.121	.001	.003	3	4
GBM	BATF3 →	+0.625	+0.105	.003	.003	3	4
LUAD	PCOLCE →	+0.765	+0.107	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044650 vs ZDHHC13 — HNSC

Explore this scatter interactively →