Adhesion of symbiont to host cell

Across TCGA cell cohorts, RNA activity of the Adhesion of symbiont to host cell pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS7B, COG2, and ASAP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LGALS7B grouped by Adhesion of symbiont to host cell-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	LGALS7B →	-3.293	-0.959	.001	<.001	3	4
BREAST	COG2 →	-0.882	-0.896	.004	.007	3	4
LARGE_INTESTINE	ASAP2 →	+0.509	+0.835	.009	.003	3	4
BLOOD_Lymphoma	CLTCL1 →	-1.950	-1.978	.004	<.001	3	4
SKIN	MAP4K5 →	-0.472	-0.887	.002	<.001	3	4
SKIN	CHURC1 →	-0.536	-1.101	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LGALS7B by Adhesion of symbiont to host cell activity — OESOPHAGUS

Explore this box plot interactively →