[4Fe-4S] cluster assembly

Across TCGA patient cohorts, RNA activity of the [4Fe-4S] cluster assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CSE1L, LYRM4, and RPRD1B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, [4Fe-4S] cluster assembly activity versus CSE1L in LSCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CSE1L →	+0.375	+0.077	<.001	<.001	3	8
OV	LYRM4 →	+0.686	+0.066	<.001	<.001	3	8
OV	RPRD1B →	+0.324	+0.062	<.001	<.001	3	7
LUAD	MRPL19 →	+0.391	+0.066	<.001	<.001	3	7
COAD	AAR2 →	+0.258	+0.035	.001	.001	3	7
OV	PRPF4B →	+0.288	+0.055	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044572 vs CSE1L — LSCC

Explore this scatter interactively →