[4Fe-4S] cluster assembly

Across TCGA cell cohorts, RNA activity of the [4Fe-4S] cluster assembly pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POP7, CLUH, and ZNF219, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POP7 grouped by [4Fe-4S] cluster assembly-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	POP7 →	-1.108	-0.210	.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	CLUH →	+1.097	+0.123	.006	.004	3	3
UPPER_AERODIGESTIVE_TRACT	ZNF219 →	+1.555	+0.122	.008	.002	3	3
UPPER_AERODIGESTIVE_TRACT	P2RY1 →	+1.584	+0.108	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	CHD3 →	+1.191	+0.111	.003	.008	3	3
CNS	JPT1 →	-0.884	-0.191	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POP7 by [4Fe-4S] cluster assembly activity — OESOPHAGUS

Explore this box plot interactively →