[4Fe-4S] cluster assembly

Across TCGA cell cohorts, RNA activity of the [4Fe-4S] cluster assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT-CYB, C16orf87, and WDR83, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, [4Fe-4S] cluster assembly activity versus MT-CYB in BREAST (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MT-CYB →	+0.818	+0.921	<.001	<.001	3	4
CNS	C16orf87 →	-0.761	-1.288	<.001	<.001	3	4
LUNG_SCLC	WDR83 →	-0.430	-1.252	.005	<.001	3	4
LUNG_SCLC	MRPS21 →	-0.472	-1.015	.006	.001	3	4
LUNG_SCLC	DPYSL2 →	-1.266	-1.393	.009	<.001	3	4
KIDNEY	GRB10 →	+1.239	+2.068	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044572 vs MT-CYB — BREAST

Explore this scatter interactively →