[2Fe-2S] cluster assembly

Across TCGA patient cohorts, RNA activity of the [2Fe-2S] cluster assembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NFS1, RPRD1B, and PIGT, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, [2Fe-2S] cluster assembly activity versus NFS1 in OV (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NFS1 →	+0.555	+0.062	<.001	<.001	3	8
LUAD	RPRD1B →	+0.227	+0.045	<.001	.001	3	6
UCEC	PIGT →	+0.408	+0.067	<.001	.001	2	7
UCEC	PIGU →	+0.575	+0.057	<.001	.007	3	6
OV	LYRM4 →	+0.545	+0.049	<.001	<.001	3	6
COAD	ERAL1 →	+0.321	+0.034	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044571 vs NFS1 — OV

Explore this scatter interactively →