[2Fe-2S] cluster assembly

Across TCGA cell cohorts, RNA activity of the [2Fe-2S] cluster assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMCHL1, HDHD3, and MRPS18A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PMCHL1 grouped by [2Fe-2S] cluster assembly-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PMCHL1 →	-0.334	-0.337	<.001	.004	3	5
LUNG_NSCLC_LUAD	HDHD3 →	-0.126	-0.332	.001	.005	3	3
OESOPHAGUS	MRPS18A →	+0.249	+0.233	.003	.001	3	3
BLOOD_Lymphoma	PRDX2 →	-0.346	-0.275	.001	.002	3	3
STOMACH	RAET1K →	-0.180	-0.396	.003	.008	3	3
SOFT_TISSUE	KMT2D →	+0.203	+0.318	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PMCHL1 by [2Fe-2S] cluster assembly activity — LUNG_SCLC

Explore this box plot interactively →