Regulation of mitochondrial mRNA stability

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial mRNA stability pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHF3_S283, DHX16_S160, and ANXA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial mRNA stability activity versus PHF3_S283 in UCEC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHF3_S283 →	+0.429	+0.081	.002	.004	3	5
OV	DHX16_S160 →	+1.049	+0.044	.003	.001	3	4
OV	ANXA2 →	-0.586	-0.032	<.001	.003	3	4
BRCA	PDE12 →	+0.312	+0.046	<.001	<.001	3	4
PDAC	WIZ_S1384 →	+0.406	+0.034	.002	.002	3	4
LSCC	ZC3H8_S59 →	+0.389	+0.028	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044528 vs PHF3_S283 — UCEC

Explore this scatter interactively →