Regulation of mitochondrial mRNA stability

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial mRNA stability pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPKAP1, SCN1B, and DNAJB6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAPKAP1 grouped by Regulation of mitochondrial mRNA stability-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MAPKAP1 →	+0.742	+0.435	<.001	.001	3	4
CNS	SCN1B →	+2.792	+0.553	<.001	.004	3	3
CNS	DNAJB6 →	+2.014	+0.553	.004	.004	3	3
SOFT_TISSUE	SYTL2 →	+4.147	+0.296	<.001	.003	3	3
CNS	TPM4 →	+3.335	+0.553	.008	.004	3	3
CNS	GNB2 →	+2.357	+0.553	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAPKAP1 by Regulation of mitochondrial mRNA stability activity — SOFT_TISSUE

Explore this box plot interactively →