Translocation of molecules into host

pathway activity — cross-omics
GO:0044417Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Translocation of molecules into host pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THOC2_T1443, UTP14A, and THOC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCTHOC2_T1443 →+0.441+0.295<.001<.00137
COADUTP14A →+0.232+0.183.004.00427
GBMTHOC2 →+0.287+0.294<.001<.00127
LSCCTHOC5 →+0.246+0.183<.001<.00136
LSCCCCAR1 →+0.193+0.209.001<.00136
BRCAPOLR1G →+0.394+0.165<.001.00236
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration