Symbiont entry into host

Across TCGA patient cohorts, RNA activity of the Symbiont entry into host pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXorf21, FGL2, and THEMIS2, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Symbiont entry into host activity versus CXorf21 in SKCM (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CXorf21 →	+1.301	+0.035	<.001	<.001	3	33
SKCM	FGL2 →	+2.325	+0.037	<.001	<.001	3	33
SCLC	THEMIS2 →	+1.767	+0.092	<.001	<.001	3	33
LAML	FGD2 →	+1.558	+0.030	<.001	<.001	3	33
SKCM	RGS18 →	+1.027	+0.034	<.001	<.001	3	33
SCLC	CLEC7A →	+2.065	+0.100	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044409 vs CXorf21 — SKCM

Explore this scatter interactively →