Symbiont entry into host

Across TCGA patient cohorts, RNA activity of the Symbiont entry into host pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYOSLID, KRT6B, and S100A8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Symbiont entry into host activity versus MYOSLID in LUAD (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MYOSLID →	+0.638	+0.143	<.001	<.001	3	6
BRCA	KRT6B →	+1.673	+0.162	.001	<.001	3	6
UCEC	S100A8 →	+2.161	+0.226	.005	.001	3	5
LSCC	SLC2A1 →	+2.315	+0.209	<.001	.001	3	5
HNSC	ADM →	+1.342	+0.186	.003	.002	3	5
HNSC	NOSTRIN →	-0.650	-0.198	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044409 vs MYOSLID — LUAD

Explore this scatter interactively →