Symbiont entry into host

Across TCGA cell cohorts, RNA activity of the Symbiont entry into host pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are A2M, RNF13, and CHST10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, A2M grouped by Symbiont entry into host-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	A2M →	-3.430	-0.722	<.001	.001	3	5
LUNG_NSCLC_LUAD	RNF13 →	-0.486	-0.212	.004	.006	3	4
UPPER_AERODIGESTIVE_TRACT	CHST10 →	-2.288	-0.223	<.001	.002	3	4
STOMACH	ADIPOR1 →	-0.583	-0.375	<.001	<.001	3	4
URINARY_TRACT	RHOB →	-2.013	-0.315	.002	.001	3	3
LARGE_INTESTINE	OSGEPL1 →	+0.695	+0.216	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

A2M by Symbiont entry into host activity — SKIN

Explore this box plot interactively →