Negative regulation of protein kinase activity by regulation of protein phosphorylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein kinase activity by regulation of protein phosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GOLGB1, THBS3, and CCDC80, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein kinase activity by regulation of protein phosphorylation activity versus GOLGB1 in CCRCC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GOLGB1 →	-0.248	-0.048	<.001	<.001	3	7
CCRCC	THBS3 →	+0.585	+0.044	.001	.003	3	6
PDAC	CCDC80 →	+0.518	+0.034	.006	.001	3	6
CCRCC	CNRIP1 →	+0.420	+0.048	<.001	<.001	3	6
BRCA	HSPG2 →	+0.385	+0.034	.001	.001	3	6
BRCA	LUM →	+0.740	+0.037	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044387 vs GOLGB1 — CCRCC

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