Protein localization to cytoskeleton

Across TCGA patient cohorts, RNA activity of the Protein localization to cytoskeleton pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SART1_S598, SON_S1769, and CTR9_T925, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cytoskeleton activity versus SART1_S598 in OV (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SART1_S598 →	+0.799	+0.367	.003	.001	3	2
OV	SON_S1769 →	+0.494	+0.441	<.001	<.001	3	2
OV	CTR9_T925 →	+1.216	+0.537	<.001	<.001	3	2
BRCA	CYBA_T147 →	-0.923	-0.534	<.001	<.001	3	2
OV	DHX8_S460 →	+0.499	+0.344	<.001	<.001	3	2
OV	AHNAK2_S1997 →	-0.844	-0.328	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044380 vs SART1_S598 — OV

Explore this scatter interactively →