Protein localization to cytoskeleton

Across TCGA cell cohorts, RNA activity of the Protein localization to cytoskeleton pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPN5, KAZALD1, and BICRAL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAPN5 grouped by Protein localization to cytoskeleton-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CAPN5 →	+1.214	+0.194	.002	.001	3	4
BLOOD_Lymphoma	KAZALD1 →	+2.833	+0.127	.001	.001	3	3
BLOOD_Lymphoma	BICRAL →	-0.864	-0.106	.002	.002	3	3
STOMACH	EXOSC3 →	-0.816	-0.277	<.001	.003	3	3
STOMACH	POLR1E →	-0.837	-0.264	.001	.002	3	3
BREAST	MRPL10 →	+0.801	+0.209	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAPN5 by Protein localization to cytoskeleton activity — BREAST

Explore this box plot interactively →