Protein localization to cytoskeleton

Across TCGA cell cohorts, RNA activity of the Protein localization to cytoskeleton pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are R3HDM2, COQ2, and BAG2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cytoskeleton activity versus R3HDM2 in PANCREAS (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	R3HDM2 →	+0.829	+0.235	<.001	<.001	3	5
OESOPHAGUS	COQ2 →	-0.813	-0.173	.001	.001	3	5
BREAST	BAG2 →	-1.287	-0.147	<.001	<.001	3	5
CNS	HHIPL2 →	-2.531	-0.153	<.001	.002	3	4
LUNG_NSCLC_LUAD	CCDC68 →	-1.129	-0.131	.002	.004	3	4
LUNG_NSCLC_LUAD	ZNF429 →	+0.914	+0.118	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044380 vs R3HDM2 — PANCREAS

Explore this scatter interactively →