Macropinocytosis

Across TCGA patient cohorts, RNA activity of the Macropinocytosis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARMIL1, FKTN, and CIZ1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macropinocytosis activity versus CARMIL1 in GBM (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CARMIL1 →	+0.863	+0.332	<.001	<.001	3	9
LSCC	FKTN →	-0.471	-0.382	<.001	.001	3	4
LSCC	CIZ1 →	-0.439	-0.438	<.001	<.001	3	4
LSCC	SCNN1G →	+0.775	+0.242	<.001	.002	3	4
OV	RNU6ATAC18P →	+1.151	+0.395	<.001	.003	3	4
LUAD	FGD1 →	-0.575	-0.203	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044351 vs CARMIL1 — GBM

Explore this scatter interactively →