Macropinocytosis

Across TCGA cell cohorts, RNA activity of the Macropinocytosis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APPL1, RAB34, and PYCARD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APPL1 grouped by Macropinocytosis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	APPL1 →	-0.198	-0.897	<.001	.002	3	6
LUNG_SCLC	RAB34 →	-0.283	-1.426	<.001	<.001	3	5
BREAST	PYCARD →	-0.218	-0.967	.001	.007	3	5
STOMACH	MICAL2 →	+0.165	+0.856	.001	.003	3	4
STOMACH	ZNF461 →	-0.180	-1.043	.001	.005	2	5
STOMACH	LIPE →	-0.210	-0.898	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APPL1 by Macropinocytosis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →