Macropinocytosis

Across TCGA cell cohorts, RNA activity of the Macropinocytosis pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOP2B, ANKHD1-EIF4EBP3, and CDK6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TOP2B grouped by Macropinocytosis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TOP2B →	+0.118	+1.476	.001	.007	3	3
LUNG_NSCLC_LUAD	ANKHD1-EIF4EBP3 →	+0.228	+0.502	.002	.009	3	3
BREAST	CDK6 →	+0.242	+0.663	.003	.007	3	3
BREAST	METTL21C →	+0.168	+0.639	.003	.001	3	3
SKIN	NFATC2IP →	-0.204	-1.297	.003	.006	3	2
STOMACH	LILRB1 →	+0.159	+1.918	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TOP2B by Macropinocytosis activity — LARGE_INTESTINE

Explore this box plot interactively →