Macropinocytosis

Across TCGA cell cohorts, RNA activity of the Macropinocytosis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYCARD, TEX9, and SLC25A47, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macropinocytosis activity versus PYCARD in BLOOD_Leukemia (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PYCARD →	+2.191	+1.291	<.001	<.001	3	7
LARGE_INTESTINE	TEX9 →	-1.228	-1.270	<.001	.001	3	4
OESOPHAGUS	SLC25A47 →	+0.110	+1.598	<.001	.001	3	4
LARGE_INTESTINE	GPLD1 →	-0.621	-0.818	.001	.008	2	4
BLOOD_Leukemia	MEF2D →	+1.234	+0.906	.002	.002	3	3
BLOOD_Leukemia	LRMDA →	+3.001	+0.918	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044351 vs PYCARD — BLOOD_Leukemia

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