Cell-cell adhesion mediated by cadherin

Across TCGA patient cohorts, RNA activity of the Cell-cell adhesion mediated by cadherin pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CPNE2, LMOD1, and SERPINA7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell adhesion mediated by cadherin activity versus CPNE2 in LSCC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CPNE2 →	+0.212	+0.044	.002	<.001	3	6
OV	LMOD1 →	+0.678	+0.047	<.001	<.001	3	6
OV	SERPINA7 →	+0.434	+0.037	<.001	<.001	3	5
CCRCC	SORBS3 →	+0.519	+0.071	<.001	<.001	3	5
BRCA	UACA →	+0.255	+0.030	.001	<.001	3	5
OV	AEBP1 →	+0.735	+0.037	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044331 vs CPNE2 — LSCC

Explore this scatter interactively →