Cell-cell adhesion mediated by cadherin

Across TCGA patient cohorts, RNA activity of the Cell-cell adhesion mediated by cadherin pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF6, CDS1, and C1orf210, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell adhesion mediated by cadherin activity versus IRF6 in LUAD (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IRF6 →	+0.610	+0.174	<.001	<.001	3	6
UCEC	CDS1 →	+0.647	+0.209	<.001	<.001	3	6
CCRCC	C1orf210 →	+1.330	+0.385	<.001	.008	3	6
UCEC	USP53 →	+0.939	+0.291	<.001	<.001	3	5
UCEC	WAS →	-0.598	-0.177	.002	.003	3	5
UCEC	ITPRID2 →	+0.794	+0.329	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044331 vs IRF6 — LUAD

Explore this scatter interactively →