Cell-cell adhesion mediated by cadherin

Across TCGA cell cohorts, RNA activity of the Cell-cell adhesion mediated by cadherin pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S1PR5, EIF3J, and UBE2D4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, S1PR5 grouped by Cell-cell adhesion mediated by cadherin-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	S1PR5 →	-1.969	-1.987	.002	<.001	3	4
BREAST	EIF3J →	+0.528	+0.959	.007	.001	3	4
PANCREAS	UBE2D4 →	-0.952	-1.032	<.001	.002	3	4
BONE	PRR34 →	-0.775	-1.545	.009	.006	3	4
BLOOD_Leukemia	RRNAD1 →	-1.004	-1.290	<.001	.002	3	4
BLOOD_Lymphoma	LAMTOR3 →	+1.033	+1.725	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

S1PR5 by Cell-cell adhesion mediated by cadherin activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →