Response to leptin

Across TCGA patient cohorts, RNA activity of the Response to leptin pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLCB1, UTRN, and HSPA14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to leptin activity versus PLCB1 in BRCA (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLCB1 →	+0.773	+0.054	<.001	<.001	3	7
OV	UTRN →	+0.258	+0.050	.009	.004	2	7
LUAD	HSPA14 →	-0.232	-0.044	.002	.008	3	6
BRCA	CORO2B →	+0.404	+0.039	<.001	<.001	3	6
BRCA	KANK3 →	+0.605	+0.064	<.001	<.001	3	6
BRCA	LYVE1 →	+0.802	+0.058	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044321 vs PLCB1 — BRCA

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