Response to leptin

Across TCGA patient cohorts, RNA activity of the Response to leptin pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTARC2, LRP2, and ASPA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to leptin activity versus MTARC2 in CCRCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MTARC2 →	+0.886	+0.200	<.001	.001	3	4
LUAD	LRP2 →	+1.728	+0.312	<.001	<.001	3	4
CCRCC	ASPA →	+0.837	+0.168	<.001	<.001	3	3
LUAD	XCL2 →	-0.858	-0.238	<.001	<.001	3	3
CCRCC	ALDH7A1 →	+0.269	+0.139	.009	.004	3	3
CCRCC	CD7 →	-0.482	-0.199	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044321 vs MTARC2 — CCRCC

Explore this scatter interactively →