Response to leptin

Across TCGA cell cohorts, RNA activity of the Response to leptin pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UGCG, PHYKPL, and D2HGDH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to leptin activity versus UGCG in LUNG_NSCLC_LUSC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	UGCG →	+1.682	+0.110	.007	.004	3	7
CNS	PHYKPL →	-0.879	-0.076	<.001	<.001	3	6
LUNG_NSCLC_LUSC	D2HGDH →	-0.913	-0.101	<.001	.007	3	6
LARGE_INTESTINE	MAP2K6 →	-1.420	-0.066	.001	.003	2	7
LUNG_NSCLC_LUSC	AP5M1 →	-0.628	-0.127	<.001	<.001	3	6
BLOOD_Leukemia	OSBPL7 →	-0.792	-0.091	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044321 vs UGCG — LUNG_NSCLC_LUSC

Explore this scatter interactively →