Cellular response to leptin stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to leptin stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PID1, PLCB1, and AKAP12_S286, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to leptin stimulus activity versus PID1 in BRCA (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PID1 →	+0.377	+0.043	.005	.004	3	7
BRCA	PLCB1 →	+0.400	+0.040	<.001	<.001	3	6
BRCA	AKAP12_S286 →	+1.035	+0.049	<.001	<.001	3	5
BRCA	PGM5_S122 →	+0.979	+0.063	.002	<.001	3	5
BRCA	TNS2 →	+0.503	+0.065	<.001	<.001	3	5
LUAD	TNS2_S941 →	+0.293	+0.052	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044320 vs PID1 — BRCA

Explore this scatter interactively →