Cellular response to leptin stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to leptin stimulus pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASGRP3, NKX6-3, and PPP1CC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RASGRP3 grouped by Cellular response to leptin stimulus-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RASGRP3 →	+0.233	+0.146	.001	.004	3	4
BLOOD_Leukemia	NKX6-3 →	+0.251	+0.126	.004	<.001	3	4
BLOOD_Leukemia	PPP1CC →	-0.200	-0.111	.007	.002	3	4
LUNG_NSCLC_LUSC	CAP1 →	-0.263	-0.093	.002	.002	3	3
LUNG_NSCLC_LUAD	LINC00311 →	+0.100	+0.128	.002	.001	3	3
LUNG_NSCLC_LUSC	GJB5 →	-0.218	-0.084	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RASGRP3 by Cellular response to leptin stimulus activity — SOFT_TISSUE

Explore this box plot interactively →