Cellular response to leptin stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to leptin stimulus pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFX1, ZIC2, and ZNF124, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to leptin stimulus activity versus RFX1 in URINARY_TRACT (Pearson r = -0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RFX1 →	-0.589	-1.665	<.001	.003	2	5
LUNG_SCLC	ZIC2 →	-2.672	-0.555	<.001	.006	3	4
BONE	ZNF124 →	-1.255	-1.725	.005	.002	3	4
OVARY	TCEANC2 →	-0.433	-0.970	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	RMI2 →	-1.925	-1.788	<.001	<.001	3	4
LUNG_NSCLC_LUSC	H4C15 →	+1.756	+1.793	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044320 vs RFX1 — URINARY_TRACT

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