Sulfur compound catabolic process

Across TCGA patient cohorts, RNA activity of the Sulfur compound catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PAICS_S27, ATAD2_S342, and XPO5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur compound catabolic process activity versus PAICS_S27 in LSCC (Pearson r = 0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PAICS_S27 →	-0.832	-0.038	<.001	<.001	3	7
LUAD	ATAD2_S342 →	-1.093	-0.027	<.001	.001	3	6
BRCA	XPO5 →	-0.505	-0.030	<.001	<.001	3	6
LUAD	MCM2_S27 →	-0.758	-0.034	.001	.008	3	6
BRCA	ORC5 →	-0.260	-0.021	<.001	<.001	3	6
LSCC	VPS4B_S93 →	-0.311	-0.034	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044273 vs PAICS_S27 — LSCC

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