Sulfur compound catabolic process

Across TCGA cell cohorts, RNA activity of the Sulfur compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP7D1, NUDT8, and ARHGEF18, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur compound catabolic process activity versus MAP7D1 in STOMACH (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MAP7D1 →	-1.300	-0.075	<.001	.003	2	12
STOMACH	NUDT8 →	+1.758	+0.107	<.001	<.001	2	12
BLOOD_Lymphoma	ARHGEF18 →	-0.724	-0.063	.002	.001	3	11
BLOOD_Leukemia	ASNS →	+2.004	+0.067	<.001	.001	3	10
BREAST	PANX1 →	-0.896	-0.068	<.001	<.001	3	10
LIVER	DSE →	-2.593	-0.112	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044273 vs MAP7D1 — STOMACH

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