Sulfur compound catabolic process

Across TCGA cell cohorts, RNA activity of the Sulfur compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDHA1, TST, and SNORC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur compound catabolic process activity versus PDHA1 in BLOOD_Lymphoma (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PDHA1 →	+0.786	+0.200	<.001	<.001	3	5
OESOPHAGUS	TST →	+1.416	+0.213	.001	.001	3	5
STOMACH	SNORC →	+1.791	+0.428	.002	.005	3	5
LARGE_INTESTINE	L1CAM →	-3.529	-0.306	.001	.003	3	5
LARGE_INTESTINE	FAM160A2 →	+0.782	+0.275	<.001	<.001	3	5
STOMACH	DNAH1 →	+1.409	+0.275	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044273 vs PDHA1 — BLOOD_Lymphoma

Explore this scatter interactively →